Objective To explore the application of early enteral nutrition and Qingyi Chengqi decoction in patients with severe acute pancreatitis (SAP), and observe its effects on immune function and intestinal mucosal barrier.Methods This study selected 86 patients with severe acute pancreatitis who were admitted to the Intensive Care Department of Linyi Traditional Chinese Medicine Hospital from January 2021 to January 2023 as the research subjects. According to different treatment methods, they were divided into a combination group and a reference group, with a ratio of 43 cases. The reference group received comprehensive care for the reference group patients, while the combination group received early enteral nutrition combined with Qingyi Chengqi Tang treatment.Compare the levels of inflammatory factors, immune function indicators, and intestinal mucosal barrier function.Results After treatment, the levels of interleukin-6 (Interleukin-6，IL-6), white blood cell (white blood cell， WBC) count, and C-reactive protein (C-reactive protein，CRP) all decreased, and the decrease in the combination group was greater than that in the reference group (P<0.05);The levels of CD3+、CD8+、and CD4+/CD8+increased after treatment, and the combined group was higher than the control group (P<0.05);The levels of diamine oxidase (diamine oxidase，DAO), lactate, and endotoxin were significantly reduced after treatment, and the combined group was significantly lower than the control group (P<0.05).Conclusion The combination of early enteral nutrition and Qingyi Chengqi Tang has a significant clinical effect on SAP patients, significantly improving the body’s immune function and intestinal mucosal barrier function, and reducing the level of inflammatory factors.
|
